AI Summary
This article explores how discrete prefrontal neuronal circuits contribute to repeated stress-induced behavioral phenotypes in male mice. The researchers identified a causal mechanism involving KDM5C's epigenetic repression of Shisa2 transcription in certain symptoms of stressed mice. This highlights the importance of understanding the specific neural circuits involved in stress responses and potential implications for treating depression.
Although depression is a highly heterogeneous syndrome, it remains unclear how stress drives individual differences in behavioral phenotypes. Utilizing a subtyping-based approach, Li, Kawatake-Kuno, Inaba, et al. found the causal mechanism of KDM5C’s epigenetic repression of Shisa2 transcription in aPVT-projecting mPFC neurons in specific symptoms of stressed mice.