AI Summary
A recent study discovered 11,000 gene regulators present in every cell type, called housekeeping cis-regulatory elements (HK-CREs). These regulators are important for maintaining cellular stability and have reduced activity in certain cancers, indicating their potential as tumor suppressors.
A recent study in genetic control elements revealed around 11,000 gene regulators active in every cell type, also known as housekeeping cis-regulatory elements (HK-CREs). These elements are vital in maintaining cellular stability beyond conventional gene regulation, influencing diverse cellular functions across healthy cell types. Moreover, a subset of these housekeeping elements, particularly those related to zinc finger genes, was found to have reduced activity in diverse cancers, suggesting their role as potential housekeeping tumor suppressors.