Nasopharyngeal carcinoma (NPC) is one of the prevalent cancers among the Asian population. Photodynamic therapy (PDT) is a novel treatment approach for NPC that eradicates its biological targets via the generation of reactive oxygen species (ROS) by the combined usage of photosensitizer (PS), molecular oxygen, and light. PDT treatment with high specificity results in an enhanced patient quality of life. Recently, researchers looking for the modulation of cellular calcium ion levels to enhance PDT efficacy.