AI Summary
Primary cilia contacts with cortical circuitry can shape and refine neuronal circuits, but disruptions in the cilia connectome can cause circuit dysfunction in brain disorders.
The unique pattern of primary cilia contacts with the surrounding cortical circuitry may enable cilia signaling to serve as a mechanism through which local environmental signals can shape and refine neuronal circuits. Disruptions in the primary cilia connectome may thus contribute to circuit dysfunction in ciliopathies and other human brain disorders.