[Comment] Traumatic brain injury research: homogenising heterogeneity

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Traumatic brain injury is a diverse condition, with different patterns of injury and outcomes. This heterogeneity can make it difficult for clinical studies to show the effectiveness of management strategies. However, measuring intracranial pressure and brain oxygen tissue pressure can help identify potential reversible secondary injuries.

Traumatic brain injury is a heterogeneous condition, and subgroups of patients with different patterns of injury, severity, and outcomes have been identified.1 This heterogeneity can limit the ability of clinical studies to show a benefit of management strategies, which might be efficacious in only a subset of patients. Measurement of intracranial pressure and brain oxygen tissue pressure (PbtO2) can help to identify a secondary injury after traumatic brain injury in a potentially reversible stage.

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