Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration

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Through deep single-cell RNA sequencing of regenerating corticospinal neurons, Kim et al. identify antioxidant response gene NFE2L2 as a new regulator of axon regeneration and develop a Regeneration Classifier that can be broadly applied to predict the regenerative potential of diverse neuronal types based on their single-cell transcriptomes.