Disrupting a core metabolic process in T cells may improve their therapeutic efficacy

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A study has found a link between the metabolism of killer T cells and their effectiveness in cancer immunotherapy, suggesting that existing drugs can be used to improve treatment.

In exploring an aspect of how killer T cells generate the raw materials required for their proliferation, a study has uncovered an unexpected link between the immune cells’ metabolism, regulation of gene expression, persistence and functional efficacy that could be exploited using existing drugs to improve cancer immunotherapy.

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