Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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The text discusses how the accumulation of amyloid beta peptides leads to Alzheimer's disease and mentions the limited knowledge about proteins that drive fibril formation and neurotoxicity.

The accumulation of amyloid beta (Aβ) peptides in fibrils is prerequisite for Alzheimer’s disease (AD). Our understanding of the proteins that promote Aβ fibril formation and mediate neurotoxicity has been lim…

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