Molecularly targetable cell types in mouse visual cortex have distinguishable prediction error responses

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O'Toole et al. found that neurons in the mouse visual cortex that respond to unexpected stimuli have distinct transcriptional identities.

O’Toole et al. investigated the relationship between transcriptional identity and computational functions in layer 2/3 of mouse visual cortex. Through a combination of in vivo functional labeling, single-cell RNA-sequencing, and cell type-specific AAVs, they demonstrate that neurons signaling unexpected stimuli are transcriptionally distinct.

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