Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling

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Kim et al. demonstrate that exercise-induced myokine irisin reduces Aβ pathology using three-dimensional (3D) cell culture model of Alzheimer’s disease (AD) and delineates the key pathways through which irisin exerts neuroprotective effects. These findings offer strong support for the development of irisin as a potential therapeutic target for AD.