AI Summary
- CAR-T-cell therapy has led to impressive recoveries in certain patients, but it is accompanied by severe and frightening side effects. - The side effects are partly due to the lymphodepleting chemotherapy that is done prior to CAR-T-cell infusion. - The text explores the possibility of conducting CAR-T-cell therapy without the need for lymphodepleting chemotherapy.
Some patients have experienced incredible recoveries after CAR-T-cell therapy. But they’ve also endured incredibly strong and scary side effects, in part because of the lymphodepleting chemotherapy that is performed before the CAR-T-cells are reinfused. What if CAR-T-cell therapy could be performed without lymphodepleting chemotherapy?