Research conducted at The Hebrew University of Jerusalem has shed light on the anti-inflammatory properties of black soldier fly larvae (BSFL) oil. Led by Prof. Betty Schwartz, from the Faculty of Agriculture, Food and Environment at the Hebrew University of Jerusalem, the study focuses on leveraging metabolomics to modulate toll-like receptor (TLR) signaling pathways. The findings hold significant promise for revolutionizing dietary approaches to inflammatory-related conditions, such as ulcerative colitis.
Ulcerative colitis, a persistent inflammatory bowel disease, often necessitates dietary adjustments. A pivotal factor is the profile of fatty acids within the diet. The research team’s investigation delves into the anti-inflammatory potential of BSFL oil, rich in medium chain fatty acids (MCFAs) like C12:0, and its potential role in mitigating inflammation linked to ulcerative colitis.
The study introduces an innovative methodology, comparing the anti-inflammatory effects of BSFL oil with those of C12:0 through the activation of cell lines (THP-1 and J774A.1) by TLR4 and TLR2. The research explores the protective effects of BSFL oil against acute colitis induced by dextran sulfate sodium (DSS). The study is published in the International Journal of Molecular Sciences.
The findings demonstrate that, while both BSFL oil and C12:0 suppress proinflammatory cytokines in