KLF12 overcomes anti-PD-1 resistance by reducing galectin-1 in cancer cells

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Krüppel-like factor 12 (KLF12) is a transcriptional inhibitor whose role in tumor immunity is unclear . It suppresses CD8^{+ T cells infiltration and function in vitro and in vivo . Mechanistically, it inhibits the expression of Gal-1 by binding with its promoter . This may serve as a novel therapeutic target for patients with immunotherapy resistance .}