AI Summary
The authors suppressed γ-secretase in human neurons and observed changes in synaptic activity and number. They found that γ-secretase regulates neurotransmitter release through the regulation of cholesterol levels.
Essayan-Perez and Südhof chronically suppressed γ-secretase in human-induced neurons to record their synaptic activity and image their synapses. They show that γ-secretase regulates the probability of neurotransmitter release and synapse number and identify that the mechanism underlying changes in synaptic transmission occurs via the regulation of cholesterol levels by γ-secretase.