Pro-SELEX is an approach for the rapid discovery of aptamers with precisely defined binding affinities that combines efficient particle display, high-performance microfluidic sorting and high-content bioinformatics. Credit: Shana Kelley, Ph.D.
Investigators led by Shana Kelley, Ph.D., the Neena B. Schwartz Professor of Chemistry, Biomedical Engineering, and of Biochemistry and Molecular Genetics, have developed a novel approach for identifying sequences of artificial DNA with differing levels of binding to other small molecules.
The approach, detailed in a study published in Nature Chemistry, could help improve the efficiency of diagnostic monitoring for patients with chronic diseases.
Aptamers are sequences of artificial DNA that selectively bind to other small molecules