AI Summary
Fear extinction is linked to changes in endocannabinoids at certain brain connections and loss of endocannabinoid signaling impairs fear extinction. This identifies a neural circuit involved in using endocannabinoids to enhance extinction.
Gunduz-Cinar et al. find that fear extinction is associated with dynamic changes in endocannabinoids at mPFC input to BLA and show that loss of endocannabinoid signaling at BLA-projecting mPFC neurons impairs fear extinction, thereby identifying a neural circuit substrate for endocannabinoid modulation of extinction.