AI Summary
Intermittent fasting can delay cognitive decline and improve conditions like stroke and Alzheimer's. However, the exact impact of glucose restriction, a part of intermittent fasting, is not fully understood. Researchers used 2-deoxyglucose to investigate how low glucose stimulates brain plasticity and treats stroke and Alzheimer's.
Intermittent fasting (IF) is a nutritional paradigm that forestalls cognitive aging, stroke disability, and Alzheimer’s progression. How glucose restriction, an aspect of IF, contributes to IF-induced benefits is unclear. Here, we used 2-deoxyglucose to elucidate how low glucose engages an evolutionarily conserved ER stress response pathway to stimulate brain plasticity and treat stroke and AD.