Customization of the translational complex regulates mRNA-specific translation to control CNS regeneration

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Select mRNAs control axon regeneration with help from specific factors like Huntingtin protein.

Schaeffer et al. demonstrate that the translational regulation of a specific subset of mRNAs is involved in the control of axon regeneration in the injured CNS. This selective translation process is controlled by the functional association of specific factors with ribosomes, such as the wild-type protein Huntingtin.

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