AI Summary
The text shows that the liver may be important in the development of Alzheimer's disease, as manipulating a specific enzyme in the liver can reduce the buildup of harmful proteins in the brain and improve cognitive abilities in animal models of the disease.
How changes in peripheral organs during aging contribute to AD pathogenesis remains unclear. Using genetic approaches, Wu et al. demonstrate that the liver plays a key role in the pathogenesis of AD. They show that hepatic sEH manipulation bidirectionally attenuated brain Aβ burden, tauopathy, and behavioral performances in AD models.