15N-amino acids from readily available 15N-nitrite (15NO2) and biomass-derived ketonic acids under ambient conditions driven by renewable electricity. Credit: ©Science China Press”> a method that is environmentally friendly for producing 15N-amino acids from readily available 15 N-nitrite ( 15NO2 ) and biomass-derived ketonic acids in an environment powered by renewable energy. Credit: Science China Press
A safe and efficient tracer tool for examining the synthesis of natural products, protein metabolism, and disease diagnosis and treatment in living organisms is provided by 15N isotope-labeled amino acids( 15N-amino acids ). Additionally, it serves as a crucial synthetic block for the synthesis of medications with 15N labels.
Currently, 15N-labeled amino acids are typically produced by microbial fermentation and chemical reduction amination of ketoacids, but these processes frequently involve difficult steps, high temperatures, or the use of toxic cyanide, which can be harmful to the environment and energy. Therefore, it is crucial to create