AI Summary
Summary: The study developed genetic methods to target specific somatostatin interneuron subtypes in the brain and found that these subtypes have specific connections with different types of pyramidal neurons, suggesting the formation of specific cortical microcircuits.
We engineered genetic methods to target the 8 major somatostatin interneuron subtypes within V1 and S1. Upon targeting particular subtypes, we found that their efferent connectivity was extremely specific to IT or PT pyramidal neuron subtypes. These results indicate that somatostatin interneurons form highly specific cortical microcircuits.