AI Summary
The study by Wang et al. reveals that the RNA-binding protein G3BP2 can inhibit the aggregation of Tau protein, which is associated with neurodegenerative disorders. This finding suggests that G3BP2 could be a potential target for developing therapies for tauopathies.
Several RNA-binding proteins (RBPs) promote pathogenic protein aggregation in neurodegenerative disorders. In contrast, Wang et al. show in this study that the RBP G3BP2 binds directly to Tau and prevents it from aggregating. This work identifies G3BP2 as a line of defense against Tau aggregation and a possible therapeutic target for tauopathies.