In a rat model of human # MultipleSclerosis, synuclein-specific CD4 + T cells invade # brain grey matter and produce an array of MS-like symptoms. It’s interesting to note that suppl materials contained the most useful distilled data points. https: // t # immunology # autoimmunedisease co / NbIt5ijxuR— March 5, 2019 David Usharauli(@ 3DiMMUNE )
highlights of the paper
2. 2. The pattern of # antigen(- synuclein ) expression was the main factor in this exclusive invasion of brain grey matter. # autoimmunedisease # immunologypic twitter.com / 1r9ROgtTDV— March 5, 2019 David Usharauli(@ 3DiMMUNE )Some ideas: in this case, the authors used either WT or transgenic rats that expressed synuclein-specific T cells. Diseases were brought on either by adoptive transfer of activated – # synuclein-specific T cell blasts or by direct immunization of transgenic rats. the # immunology— March 5, 2019 David Usharauli(@ 3DiMMUNE )
Con’t: Although immunologists have a good understanding of the mechanisms that make up immune response, it is still unclear how the response is initiated naturally or stopped. The current experimental models in # immunology have their Achilles heels.— March 5, 2019 David Usharauli(@ 3DiMMUNE )