According to a recent study from Bacher / Scheffold lab, gut commensal pathobiont # Candida # albicans via # crossreactivity has expanded the IL – 17 + T cell response to airborne # fungus like # Aspergillus fumigatus found in people with # asthma, # COPD, and CF.— David Usharauli on February 23, 2019 (@ 3DiMMUNE )
1. Specific C. albicans make up the majority of the IL-17 + # T cells found in healthy donors. Immunology # TH17 # fungipic Twitter.com / WITidrcCn— David Usharauli on February 23, 2019(@ 3DiMMUNE )
3. 3. In fact, the IL – 17 + T cells specific for A. fumigatus were # crossreactive to C. albicans when they were depleted from the # Aspergillus fumigatus-specific T cell pool. pic. twitter.com / cZEu50Uwep— David Usharauli on February 23, 2019(@ 3DiMMUNE )
5. In people with# crohnsdisease, similar expansion of Aspergillus fumigatus-specific T cells producing IL-17 was also seen. pic. L0VbmCcFj5 twitter.com— David Usharauli on February 23, 2019(@ 3DiMMUNE )
Any # immunopathology caused by an excess of IL – 17 response must be the result of some other changes in the host that make it susceptible to pathology since both # fungi are naturally present. What? ?— David Usharauli on February 23, 2019(@ 3DiMMUNE )