11 microbial species from the human faecal # microbiota were found in a new study @ nature by Japanese scientists( Konda, Atarashi, & amp, etc. ) that increased# IFN – gamma + # CD8 T cells protective against # infection and # tumors.— David Usharauli on January 24, 2019 (@ 3DiMMUNE )
2. 2. Even these 11 strains of # consortium could be further categorized into two groups of 4 non-Bacteroides species and 7 # bacteriales. However, when CD8 T cells were separated, the effect was largely lost. pic. UOzqWNFJQz on twitter.com— David Usharauli on January 24, 2019 (@ 3DiMMUNE )
3. 3. Significantly, the consortium’s impact on T cells was# biologically significant because it enhanced# protection against# pathogen challenge. pic. twitter.com / Wotr8HJ4p5— David Usharauli on January 24, 2019(@ 3DiMMUNE )
5. 5. However, in SPF mice( regular lab mouse ), the # tumor protective effect of this consortium alone was less obvious. However, the combination of # consortium + # checkpoint inhibitors exhibits a # synergy even in SPF mice. pic. H9Iyv13E0o twitter.com— David Usharauli on January 24, 2019 (@ 3DiMMUNE )
Scientifically speaking, this paper is not very significant. It lacks the mechanisms and granularity found in excellent papers. However, a number of authors, including the senior author, work for the microbiota biotech company @ VedantaBio, where these data may be sufficient for investment.— David Usharauli on January 24, 2019(@ 3DiMMUNE )