The # Treg differentiation potential of # CD25 + and Foxp3( low ) precursors in the ## thymus was compared in a recent study published in @ NatImmunol. http :// t.co / rIFWqybNnmpic.twitter.com / 9ibTGBeHF9— David Usharauli on January 22, 2019 (@ 3DiMMUNE )
2. 2. Reliance on # IL4 # signaling to generate Tregs only from Foxp3( low ) precursors( both responded to IL – 2 ) was an intriguing # difference between CD25 + and FOXp3, which were both low) # precursors. pic. twitter.com / hNoLxVBfIP— David Usharauli on January 22, 2019 (@ 3DiMMUNE )
In conclusion, Tregs can be produced by two different kinds of thymic precursors. Given the differences in tissue inflammation protection, their # TCR did not overlap with one another but instead overlapped with mature # Foxp3 + # tregs, indicating a certain # functional bifurcation.— David Usharauli on January 22, 2019(@ 3DiMMUNE )
