Ag-specific or not Ag-specific, that is [maybe was] question for #Foxp3+ Tregs mechanism of action. New paper in @NatImmunol from #Shevach‘s lab @NIH says definitely antigen-specific. Lets dive in. BTW, ~20 years ago his lab developed assays that showed it was non-specific 🤫
— David Usharauli (@3DiMMUNE) January 16, 2019
Now his lab made U-turn and concluded that #suppression by #Tregs is actually #antigen-specific and difference between now and then comes down to in #vitro versus in #vivo assays 🤔
— David Usharauli (@3DiMMUNE) January 16, 2019
2. This #antigen-specific #suppression was still active when antigen-specific dendrtic cells were removed from Treg co-culture (1st culture) and exposed to T cells (2nd culture). pic.twitter.com/dj1pzDuNNv
— David Usharauli (@3DiMMUNE) January 16, 2019
So, from now on if someone asks you how Treg suppress other T cells don’t hesitate to reply “antigen-specific manner”, add Ethan Shevach said so and no one will argue with you. got it 🤨 https://t.co/I4pAYIIGy1
— David Usharauli (@3DiMMUNE) January 16, 2019